Epilepsy on high-risk pregnancy and perinatal outcomes

Authors

DOI:

https://doi.org/10.36489/saudecoletiva.2022v12i74p9922-9933

Keywords:

Epilepsy, Prenatal care, High-risk pregnancy

Abstract

Objective: To analyze the perinatal outcomes of pregnant women with epilepsy as a pre-existing clinical condition. Method: This is an epidemiological, observational and retrospective study with a quantitative approach. The population was constituted from the research of all medical records, reports and cards of pregnant women attended and classified as high risk with Pre-Existing Clinical Condition of Epilepsy and attended at the high risk reference clinic of the 15th Regional Health, located in the city of Maringá/PR. Results: It was observed that there was no significant association between epilepsy as a pre-existing clinical condition and perinatal outcomes. Conclusion: Although pregnancy associated with epilepsy is considered high risk, adequate follow-up in an outpatient clinic specializing in high-risk prenatal care and the Basic Health Unit during prenatal care significantly contributes to reducing the rate of obstetric, maternal and fetal.

Author Biographies

Rebecca Christophoro Packer

University Center of Maringá — Unicesumar - medical student

Lincoln Tsuyoshi Sato

University Center of Maringá — Unicesumar - Academic of Medicine

Flavia Cristina Vieira Frez

PhD in Pharmaceutical Sciences - State University of Maringá -UEM - Professor / Researcher

Patricia Bossolani Charlo

Doctoral Student in Nursing - State University of Maringá UEM - Professor / Researcher

Sandra Marisa Pelloso

Doctor in Nursing - State University of Maringá - UEM - Professor / Researcher

Marcos Benatti Antunes

Doctor in Nursing - State University of Maringá - UEM - Professor / Researcher

References

Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, et al. Relato oficial da ILAE: Uma definição prática de epilepsia.

Harden C, Lu C. Epilepsy in Pregnancy. Vol. 37, Neurologic Clinics. W.B. Saunders; 2019. p. 53–62.

Scheffer IE, Berkovic S, Capovilla G, Connolly MB, French J, Guilhoto L, et al. Classificação da ILAE das epilepsias: artigo da posição da Comissão de Classificação e Terminologia da InternationalLeagueagainstEpilepsy.

Tomson T, Battino D, Bromley R, Kochen S, Meador K, Pennell P, et al. Executive Summary: Management of epilepsy in pregnancy: A report from the International League Against Epilepsy Task Force on Women and Pregnancy. Epilepsia. 2019 Dec 1;60(12):2343–5.

Sen A, Nashef L. New regulations to cut valproate-exposed pregnancies. Vol. 392, The Lancet. Lancet Publishing Group; 2018. p. 458–60.

Paolini SL, Pilato M, Rajasekaran V, Waters JFR, Bagic A, Urban A. Outcomes in three cases after brivaracetam treatment during pregnancy. Vol. 141, ActaNeurologicaScandinavica. Blackwell Publishing Ltd; 2020. p. 438–41.

Damar U, Lee Kaye H, Smith NA, Pennell PB, Rotenberg A. Safety and Tolerability of Repetitive Transcranial Magnetic Stimulation during Pregnancy: A Case Report and Literature Review. Vol. 37, Journal of Clinical Neurophysiology. Lippincott Williams and Wilkins; 2020. p. 164–9.

Meador KJ, Pennell PB, May RC, Brown CA, Baker G, Bromley R, et al. Effects of periconceptional folate on cognition in children of women with epilepsy: NEAD study. Neurology. 2020 Feb 18;94(7):e729–40.

Soontornpun A, Choovanichvong T, Tongsong T. Pregnancy outcomes among women with epilepsy: A retrospective cohort study. Epilepsy and Behavior. 2018 May 1;82:52–6.

KusznirVitturi B, Barreto Cabral F, MellaCukiert C. Outcomes of pregnant women with refractory epilepsy. Seizure. 2019 Jul1;69:251–7.

Lorenzato RZ, de Carvalho Cavalli R, Duarte G, Sakamoto AC, Filho FM, Nogueira AA, et al. Epilepsia e Gravidez: Evolução e Repercussões EpilepsyandPregnancy: Evolutionand Fetal Outcome.

Razaz N, Tomson T, Wikström AK, Cnattingius S. Association between pregnancy and perinatal outcomes among Women with epilepsy. JAMA Neurology. 2017 Aug 1;74(8):983–91.

Viale L, Allotey J, Cheong-See F, Arroyo-Manzano D, McCorry D, Bagary M, et al. Epilepsy in pregnancy and reproductive outcomes: A systematic review and meta-analysis. The Lancet. 2015 Nov 7;386(10006):1845–52.

Putignano D, Clavenna A, Campi R, Canevini MP, Vignoli A, Battino D, et al. Perinatal outcome and healthcare resource utilization in the first year of life after antiepileptic exposure during pregnancy. Epilepsy and Behavior. 2019 Mar 1;92:14–7.

Galappatthy P, Liyanage CK, Lucas MN, Jayasekara DTLM, Abhayaratna SA, Weeraratne C, et al. Obstetric outcomes and effects on babies born to women treated for epilepsy during pregnancy in a resource limited setting: A comparative cohort study. BMC Pregnancy and Childbirth. 2018 Jun 14;18(1).

Salman L, Shmueli A, Ashwal E, Hiersch L, Hadar E, Yogev Y, et al. The impact of maternal epilepsy on perinatal outcome in singleton gestations. Journal of Maternal-Fetal and Neonatal Medicine. 2018 Dec 17;31(24):3283–6.

Allotey J, Aroyo-Manzano D, Lopez P, Viale L, Zamora J, Thangaratinam S. Global variation in pregnancy complications in women with epilepsy: A meta-analysis. European Journal of Obstetrics and Gynecology and Reproductive Biology. 2017 Aug 1;215:12–9.

Sveberg L, Svalheim S, Taubøll E. The impact of seizures on pregnancy and delivery. Vol. 28, Seizure. W.B. Saunders Ltd; 2015. p. 29–32.

Fernandes da Silva A, Iuçara Lourenço de Oliveira F, Mendes Tomaz P, Dantas Pinto Coura MK, Silva de Queiroga J, Karoline Morais da Silva L. Implantação do pré-natal de alto risco em um hospital no Alto Sertão: relato de experiência. SaudColetiv (Barueri) [Internet]. 2021. 11(69):7890-7.

Joung WJ. Pregnancy and Childbirth Experiences of Women with Epilepsy: A Phenomenological Approach. AsianNursingResearch. 2019 May 1;13(2):122–9.

Published

2022-03-22

How to Cite

Rebecca Christophoro Packer, Lincoln Tsuyoshi Sato, Flavia Cristina Vieira Frez, Patricia Bossolani Charlo, Sandra Marisa Pelloso, & Marcos Benatti Antunes. (2022). Epilepsy on high-risk pregnancy and perinatal outcomes. Saúde Coletiva (Barueri), 12(74), 9922–9933. https://doi.org/10.36489/saudecoletiva.2022v12i74p9922-9933

Issue

Section

Artigos Cientí­ficos