Vitamina D e seus efeitos na prevenção de doenças
DOI:
https://doi.org/10.36489/saudecoletiva.2022v12i80p11450-11465Palavras-chave:
Vitamina D, Deficiência de Vitamina D, Fatores ImunológicosResumo
Objetivo: Analisar os níveis ótimos de vitamina D no organismo e seus efeitos na prevenção de doenças. Método: Trata-se de um estudo de revisão integrativa. Foram selecionados artigos entre 2016 e 2020 nas bases de dados Pubmed, Scielo, BDENF e Science Direct de março a julho de 2021. A padronização dos descritores foi realizada por meio dos Descritores em Ciências da Saúde e pelo Medical Subject Headings. Foi utilizado o operador booleano “AND”. Resultados: Após aplicar todos os critérios de inclusão, houve 14 artigos que compuseram a amostra final, os quais responderam à questão de pesquisa. Estudos demonstraram os efeitos benéficos da vitamina D em diferentes patologias, entre essas para a COVID-19, asma, pneumonia, rinite alérgica, síndrome pré-menstrual, produção de imunidade, fibrose cística e tireoidite de Hashimoto. Conclusão: São muitos os benefícios da vitamina D, tais como potente anti-inflamatório, regulação de infecções e equilíbrio do sistema imune.
Referências
Aguilar Shea AL, Moreno-Arrones OM, Martinez DP, Vaño-Galván S. Vitamina D para la práctica diária. Semergen. 2020 Mar; 46 (6): 406-10. doi: https://doi.org/10.1016/j.semerg.2020.02.008
Zhu M, Tan Z, Luo Z, Hu H, Wu T, Fang S, et al. Association of the vitamin Detabolism gene GC and CYP27B1 polymorphisms with cancer susceptibility: a meta-analysis and trial sequential analysis. Biosci. Rep. 2019 Sept; 39(9). doi: https://doi.org/10.1042/BSR20190368
Chang SW, Lee HC. Vitamin D and health – The missing vitamin in humans. Pediatrics and Neonatology. 2019 Apr; 60: 237-44. doi: https://doi.org/10.1016/j.pedneo.2019.04.007
Enechukwu, N, Cockburn M, Ogun, G, Ezejiofor, OI, George A, Ogunbiyi, A. Higher vitamin D levels in Nigerian albinos compared with pigmented controls. International Journal of Dermatology. 2019 Aug; 58 (10):1148-52. doi: https://doi.org/10.1111/ijd.14611
Webb AR, Kazantzidis A, Kift, RC, Farrar MD, Wilkinson J, Rhodes LE. Colour Counts: Sunlight and Skin Type as Drivers of Vitamin D Deficiency at UK Latitudes. Nutrients. 2018 Apr; 10(4): 457. doi: https://doi.org/10.3390/nu10040457
Vitamina D: novos valores de referência [Internet] Sociedade Brasileira de Endocrinologia e Metabologia. Out 2017 [acesso em 2021 out 23]. Disponível em: https://www.endocrino.org.br/vitamina-d-novos-valores-de-referencia/#:~:text=Recentemente%20a%20Sociedade%20Brasileira%20de,partir%20de%2020%20ng%2FmL
Roth DE, Abrams AS, Aloia J, Bergeron G, Bourassa MW, Brown, KH, et al. Global prevalence and disease burden of vitamin D deficiency: a roadmap for action in low‐ and middle‐income countries. Ann NY Acad Sci. 2018 Sept; 1430(1) 44-79. doi: https://doi.org/10.1111/nyas.13968
Vitamin D Fact Sheet for Health Professionals [Internet]. National Institutes of Health. 2020 Oct [cited 2021 Oct 23]. Available from: https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/#change
Amrein K, Scherkl M, Hoffmann M, Neuwersch-Sommeregger S, Köstenberger M, Berisha TA, et al. Vitamin D deficiency an update on the current status worldwide. European Journal of Clinical Nutrition. 2020 Jan; 74:1498-513. doi: https://doi.org/10.1038/s41430-020-0558-y
Grant WB, Lathore H, McDonnell SL, Baggerly CA, French CB, Aliano JL, et al. Evidence that vitamin D supplementation could reduce the risk of influenza and COVID-19 infections and deaths. Nutrients. 2020 Apr; 12(4):988. doi: https://doi.org/10.3390/nu12040988
Castillo ME, Costa LME, Barrios JMV, Díaz JFA, Miranda JL, Bouillon R, et al. “Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study”. Journal of Steroid Biochemistry and Molecular Biology. 2020 Aug; 203:105751. doi: https://doi.org/10.1016/j.jsbmb.2020.105751
Uday S, Hogler W. Nutritional rickets and osteomalacia in the twenty-first century: revised concepts, public health and prevention strategies. Curr. osteoporos rep. 2017 June; 15: 293-302. doi: https://doi.org/10.1007/s11914-017-0383-y
Ribeiro RP, Aroni P. Standardization, ethics and biometric indicators in scientific publication: integrative review. Rev. Bras. Enferm. 2019 Nov/Dec; 72(6):1723-9. doi: https://doi.org/10.1590/0034-7167-2018-0283
Ahmed AE, Hassan MH, Toghan R, Rashwan NI. Analysis of 25-hydroxy cholecalciferol, immunoglobulin E, and vitamin D receptor single nucleotide polymorphisms (Apa1, Taq1, and Bsm1), among sample of Egyptian children with bronchial asthma: A case-control study. Pediatric Pulmonology. 2020 June; 55(6):1349-1358. doi: https://doi.org/10.1002/ppul.24785
Chahardoli R, Saboor-Yaraghi AA, Amouzegar A, Khalili D, Vakili AZ, Azizi F. Can supplementation with vitamin D modify thyroid autoantibodies (Anti-TPO Ab, Anti-Tg Ab) and thyroid profile (T3, T4, TSH) in Hashimoto's thyroiditis? A double blind, randomized clinical trial. Horm. metabol. res. 2019 May; 51(5): 296-301. doi: 10.1055/a-0856-1044.
Haugen J, Basnet S, Hardang IM, Sharma A, Mathisen M, Shrestha P, et al. Vitamin D status is associated with treatment failure and duration of illness in Nepalese children with severe pneumonia. Pediatric Research. 2017 Dec. 82 (6): 986 – 993. doi: 10.1038/pr.2017.71.
Heidari H, Amani R, Feizi A, Askari G, Kohan S, Tavasoli P. Vitamin D supplementation for premenstrual syndrome-related inflammation and antioxidant markers in students with vitamin D deficient: a randomized clinical trial. Sci. rep. 2019 Oct; 17;9 (1): 14939. doi: 10.1038/s41598-019-51498-x.
Jain A, Chaurasia R, Sengar SN, Singh M, Mahor S, Narain S. Analysis of vitamin D Level among asymptomatic and critically ill COVID-19 patients and its correlation with inflammatory markers. Sci Rep. 2020 Nov; 10(1): 20191. doi: 10.1038/s41598-020-77093-z.
Kanhere M, He J, Chassaing B, Ziegler TR, Alvarez JA, Ivie EA et al. Bolus weekly vitamin D3 supplementation impacts gut and airway microbiota in adults with cystic fibrosis: A double-blind, randomized, placebo-controlled clinical trial. J. clin. endocrinol. metab. 2018 Feb; 103(2):564-574. https://doi.org/10.1210/jc.2017-01983
Kaufman HW, Niles JK, Kroll MH, Bi C, Holick MF. SARS-COV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels. PLOS ONE. 2020 Sept; 15(9): e0239252. doi: https://doi.org/10.1371/journal.pone.0239252
Liu ZQ, Li MG, Geng XR, Liu J, Yang G, Qiu SQ et al. Vitamin D regulates immunoglobulin mucin domain molecule-4 expression in dendritic cells. Clinical e Experimental Allergy. 2017 May; 47(5): 656-664. doi: https://doi.org/10.1111/cea.12894
Miroliaee AE, Salamzadeh J, Shokouhi S, Sahraei Z. The study of vitamin D administration effect on CRP and Interleukin-6 as prognostic biomarkers of ventilator associated pneumonia. Jornal of Critical Care. 2018 Apr; 44: 300 - 305. doi: https://doi.org/10.1016/j.jcrc.2017.08.040
Mohammadzadeh I, Darvish S, Oujeq D, Hajiahmadi M, Vaghari-Tabari M. Association of serum 25-OH vitamin D3 with serum IgE and the pediatric asthma severity score in patients with pediatric asthma. Allergy asthma proc. 2020 May; 41(2): 126-133. doi: https://doi.org/10.2500/aap.2020.41.190025
Mulrennan S, Knuiman M, Walsh JP, Hui J, Hunter M, Divitini M et al. Vitamina D and Respiratory health in the Busselton healthy ageing study. Asian Pacific Society of Respirology. (Carlton South). 2018 June; 23(6): 576-582. doi: https://doi.org/10.1111/resp.13239
Ohaegbulam KC, Mohamed S, Patel P, Smith MA, Perrin R, et al. Vitamin D supplementation in COVID-19 patients: A clinical case series. American Journal of Therapeutics. 2020; 27(5): e485-e490. doi: 10.1097 / MJT.0000000000001222
Solidoro P, Bellocchia M, Aredano I, Mattei A, Pivetta E, Patrucco F et al. Asthmatic patients with vitamin D deficiency have decreased exacerbations after vitamin replacement. Nutrients. 2017 Nov; 9(11): 1234. doi: https://doi.org/10.3390/nu9111234
Tayel AI, Soliman SE, Elsayed HM. Vitamin D deficiency and vitamin D receptor variants in mothers and their neonates are risk factors for neonatal sepsis. Steroids. 2018 June; 134:37-42. doi: https://doi.org/10.1016/j.steroids.2018.03.003
Meltzer DO, Best TJ, Zhang H, Vokes T, Arora V, Solway J. Association of Vitamin D Status and Other Clinical Characteristics with COVID-19 Test Results. JAMA Netw.Open. 2020 Sept; 3:e2019722. doi: 10.1001/jamanetworkopen.2020.19722.
Katz J, Yue S, Xue W. increased risk for covid-19 in patients with vitamin d deficiency. Nutrition. 2021 Apr; 84:111106. doi: 10.1016/j.nut.2020.111106
Cannell JJ, Vieth R, Umhau JC, Holick MF, Grant WB, Madronich S et al. Epidemic influenza and vitamin D. epidemiol. infect. 2006 Dec; 134:1129–1140. doi: 10.1017/S0950268806007175
Crane-Godreau MA, Clem KJ, Payne P, Fiering S. Vitamin D deficiency and air pollution exacerbate COVID-19 through suppression of antiviral peptide LL37. Front. Public Health. 2020 May; 8:232. doi: 10.3389/fpubh.2020.00232
Cervero M, Lopez-Wolf D, Casado G, Novella-Mena M, Ryan-Muruá P, Taboada-Martínez ML. Beneficial Effect of Short-Term Supplementation of High Dose of Vitamin D 3 in Hospitalized Patients With COVID-19: A Multicenter, Single-Blinded, Prospective Randomized Pilot Clinical Trial. Front Pharmacol. 2022 Jul;13: 863587. doi: 10.3389/fphar.2022.863587
Mahdavi AM. A brief review of interplay between vitamin D and angiotensin-converting enzyme 2: Implications for a potential treatment for COVID-19. Reviews in Medical Virology. 2020 June; 30(5): e2119. doi: https://doi.org/10.1002/rmv.2119
Aziz DA, Abbas A, Viquar W, Munawar Hussain A. Association of vitamin D levels and asthma exacerbations in children and adolescents: Experience from a tertiary care
center. Monaldi Arch Chest Dis. 2022. doi: 10.4081/monaldi.2022.2230
Wang M, Liu M, Wang C, Xiao Y, An T, Zou M, Cheng G. Association between vitamin D status and asthma control: A meta-analysis of randomized trials. Respir Med. 2019 Apr; 150:85-94. doi: 10.1016/j.rmed.2019.02.016.
Han YY, Forno E, Bacharier LB, Phhipatanakul W, Guilbert TW, Cabana MD et al. Vitamin D supplementation, lung function and asthma control in children with asthma and low vitamin D levels. Eur Respir J. 2021 Oct; 58(4). doi: https://doi.org/10.1183/13993003.00989-2021
Yaghoobi MH, Taher A, Seifrabie MA, Sabahi M, Rahimi-Bashar F. Serum vitamin D level was not associated with severity of ventilator associated pneumonia. Rom. J. Intern. Med. 2019; 57 (1): 55–60. doi: https://doi.org/10.2478/rjim-2018-0033
Akeredolu FD, Akuse RM, Mado SM, Yusuf R. Relationship Between Serum Vitamin D Levels and Acute Pneumonia in Children Aged 1–59 Months in Nigeria. Journal of Tropical Pediatrics. 2021 Feb; 67 (1). doi: https://doi.org/10.1093/tropej/fmaa101
Alnori H, Alassaf FA, Alfahad M, Qazzaz ME, Jasim M, Abed MN. Vitamin D and Immunoglobulin E Status in Allergic Rhinitis Patients Compared to Healthy People. Journal of medicine and Lif. 2020; 13 (4): 463–468. doi: 10.25122/jml-2020-0015
Bahrami A, Avan A, Sadeghnia HR, Esmaeili H, Tayefi M, Ghasemi F et al. High dose vitamin D supplementation can improve menstrual problems, dysmenorrhea, and
premenstrual syndrome in adolescentes. Gynecological Endocrinology. 2018 Feb; 34 (8): 659-63. doi: https://doi.org/10.1080/09513590.2017.1423466
Hornsby E, Pfeffer PE, Laranjo N, Cruikshank W, Tuzova M, Litonjua AA, Weiss ST, Carey VJ, O'Connor G, Hawrylowicz C. Vitamin D supplementation during pregnancy: Effect on the neonatal immune system in a randomized controlled trial. J Allergy Clin Immunol. 2018 Jan;141(1):269-278.e1. doi: 10.1016/j.jaci.2017.02.039.
Websky VK, Hasan AA, Reichetzeder C, Tsuprykov O, Hocher B. Impact of vitamin D on pregnancy-related disorders and on offspring outcome. J Steroid Biochem Mol Biol. 2018 Jun; 180:51-64. doi: 10.1016/j.jsbmb.2017.11.008.
Daley T, Hughan K, Rayas M, Kelly A, Tangpricha V. Vitamin D deficiency and its treatment in cystic fibrosis. J Cyst Fibros. 2019 Oct;18 Suppl 2:S66-S73. doi: 10.1016/j.jcf.2019.08.022.
Krysiak R, Szkróbka W, Okopień B. The Effect of Gluten-Free Diet on Thyroid Autoimmunity in Drug-Naïve Women with Hashimoto's Thyroiditis: A Pilot Study. Exp Clin Endocrinol Diabetes. 2019 Jul;127(7):417-422. doi: 10.1055/a-0653-7108.
Mikulska AA, Karaźniewicz-Łada M, Filipowicz D, Ruchała M, Główka FK. Metabolic Characteristics of Hashimoto's Thyroiditis Patients and the Role of Microelements and Diet in the Disease Management-An Overview. Int J Mol Sci. 2022 Jun;23(12):6580. doi: 10.3390/ijms23126580.
