C-reactive protein important biomarker of cardiometabolic risk in childhood obesity

Abstract

To establish the importance of evaluating ultrasensitive C-reactive protein (hs-CRP) as a biomarker in an obese pediatric group, detecting possible cardiometabolic complications early. This is a case-control study involving 342 children and adolescents, from the Preventive Medicine Service, Aracaju-Sergipe, Brazil. 235 obese and 107 controls participated in the study. The CRP-us showed a mean value of 2.36 ± 1.28 mg / dL in the obese group and 0.01 ± 0.1 mg / dL in the control group. There was a significant correlation between the increase in hs-CRP in the obese group and biochemical and anthropometric findings such as: reduced HDL, elevated triglycerides and with the highest indicators of body mass index and abdominal circumference. Homocysteine proved to be a poorly specific biomarker in this study. Therefore, ultrasensitive C-reactive protein has been shown to be a biomarker of cardiometabolic risk, presenting high sensitivity in our pediatric population with obesity.