Avaliação da Alfa-1-Glicoproteí­na ácida e Mucoproteí­nas em pacientes com Paracoccidioidomicose tratados com Sulfametoxazol-Trimetoprim

Paula Layana  Vieira Wanderley; Carlos Eduardo  Tortelli Veloso; Tâmara  Vieira Monção; Danille  Ferreira de Oliveira

doi:10.36489/saudecoletiva.2021v11i67p6691-6704

Authors

Paula Layana Vieira Wanderley
Carlos Eduardo Tortelli Veloso
Tâmara Vieira Monção
Danille Ferreira de Oliveira

DOI:

https://doi.org/10.36489/saudecoletiva.2021v11i67p6691-6704

Keywords:

Paracoccidioidomycosis, Mucoproteins, Medication Adherence

Abstract

Alpha-1-acid glycoprotein (AGP) and mucoprotein are proteins of the inflammatory phase that increase their plasma concentrations when they present a response to the inflammatory state, representing a defense mechanism of the organism. The aim of the study was to evaluate the profile of these proteins in patients with chronic PCM treated with sulfamethoxazole-trimethoprim (SMX-TMP) and to associate the results found with epidemiological data, risk factors, symptoms, disease progression, and treatment outcome. In the methods adopted, the medical records of 244 patients with chronic PCM from 1998 to 2014 were analyzed. Of these, 134 (54.92%) patients underwent biochemical tests for inflammatory proteins during the course of the disease. Adult patients aged 30 to 50 years predominated 73 (54.48%), smokers 123 (91.79%), alcoholics 60 (44.78%). As a result, there was a decrease in inflammatory proteins after treatment (p = 0.01803). In conclusion, AGP and mucoproteins are useful as markers of the effect of therapy and inflammatory involution.

Author Biographies

Paula Layana Vieira Wanderley

Specialist in Family Health from the Federal University of Rio Grande do Norte-UFRN (2020) Graduated in Medicine from the Faculty of Biomedical Sciences of Cacoal/RO-FACIMED (2018). Currently she works as a Primary Care Physician and in the area of Clinical Medicine.

Carlos Eduardo Tortelli Veloso

Specialist in Family Health from the Federal University of Rio Grande do Norte-UFRN (2020) Graduated in Medicine from the Faculty of Biomedical Sciences of Cacoal/RO-FACIMED (2018). Currently, he works as a Primary Care Physician and in the area of Medical Clinic.

Tâmara Vieira Monção

Medical student at the Federal University of Roraima, UFRR (10th semester).

Danille Ferreira de Oliveira

Resident of the Gynecology and Obstetrics course at Maria Aparecida Pedrossian University Hospital, Federal University of Mato Grosso do Sul (UFMS). Graduated in Medicine at the Faculty of Biomedical Sciences of Cacoal/RO-FACIMED (2018). Currently she works as a Doctor in the area of Clinical Medicine.