Diagnosis of pediatric multisystemic inflammatory syndrome associated with COVID-19

Abstract

SARS-CoV-2 may have caused an increase in cases of Pediatric Multisystem Inflammatory Syndrome (P-SIM), causing shock and organ failure. The aim of the article was to elucidate what to evaluate to diagnose SIM-P associated with COVID-19. Method: Literature review on the Evidence Aid and Pubmed platform with the descriptors: pediatric multisystem inflammatory syndrome and COVID-19. 89 articles were found, selecting 26 after screening. Two epidemiological bulletins and a post from the Society of Pediatrics of São Paulo were manually added. Results: The epidemiological aspects, the presence of fever, skin rash and gastrointestinal and cardiac alterations, help to characterize the syndrome. Laboratory tests show an increase in: C-reactive protein, D-dimer, procalcitonin, serum ferritin, fibrinogen and cardiac markers. Conclusion: The identification of alterations is crucial for the differential and correct diagnosis of P-SIM. Furthermore, the standardization of data collection and the identification and description of signs and symptoms would cooperate for the diagnosis.