Lack of non-quantitative effectiveness of drugs for diabetes: aspects of clinica! pharmacology and pharmaceutical chemistry

Authors

  • Luciano Henrique Pinto
  • Micael Batista Pereira Santos
  • Thais Laini Simões
  • Marian Felisberto Bitencourt
  • Hauana Heilig Martins
  • Luciana Ferreria Karstens

DOI:

https://doi.org/10.36489/saudecoletiva.2021v11i69p8046-8057

Keywords:

Unified Health System, Drug Therapy, Evaluation of the Efficacy-Effectiveness of lnterventions, Diabetes Mellitus

Abstract

Objective: to problematize and alert to non-quantitative issues involving non-therapeutic success in patients with Diabetes Mellitus li (DM li). Method: the study carried out in two Basic Family Health Unit Centers, in Joinville city, Santa Catarina State, Brazil. The studied population corresponded to users of chronic DM li drugs; under drug treatment and registered in medical records. Data collection took place through interviews and analysis of medical records. Results: A total of 222 patients, between 42 and 82 years old, were selected in the study. The analysis of the presence of factors that lead to lack of non-quantitative effectiveness (FLNQE) resulted in an average of 3.09 causes of non-effectiveness per patient. Conclusion: FLNQE are present, especially in newly diagnosed and polypharmacy patients, also with age as a contributing factor. New studies have helped to better understand this phenomenon.

Author Biographies

Luciano Henrique Pinto

Professor adjunto de farmacologia e química farmacêutica. Departamentos de Medicina, Enfermagem e Farmácia, Universidade da Região de Joinville, UNIVILLE, Coordenador do Projeto Integrado ECOSAM. ORCID: 0000-0003-0250-7502

Micael Batista Pereira Santos

Graduandos em Farmácia, Universidade da Região de Joinville, UNIVILLE. ORCID: 0000-0003-3347-8847

Thais Laini Simões

Graduandos em Farmácia, Universidade da Região de Joinville, UNIVILLE.
ORCID: 0000-0002-9547-9522

Marian Felisberto Bitencourt

Graduandas em Medicina, Universidade da Região de Joinville, UNIVILLE. ORCID: 0000-0003-1467-3356

Hauana Heilig Martins

Graduandas em Medicina, Universidade da Região de Joinville, UNIVILLE. ORCID: 0000-0003-1003-037X

Luciana Ferreria Karstens

Professora Adjunto, Departamentos de Enfermagem, Universidade da Região de Joinville, UNIVILLE, Colaboradora do Projeto Integrado ECOSAM. ORCID: 0000-0001-9843-3047

References

Mateus Santos Paula lglésias Ferreira Patrícia Lopes Ribeiro H. Introdução Ao Seguimento Farmacoterapêutico. http:#www. saude.sp.gov.br/resources/ipgg/assistencia-farmaceutica/gicuf-introducaoaoseguimentofarmacoterapeutico.pdf. 2. Pereira TTSO, Barros MN dos S, Augusto MCN de A. Mental : Revista de Saúde Mental e Subjetividade Da UNIPAC. Vai 9. Universidade Presidente Antonio Carlos; 2004. http ://pepsic. bvsal u d .org/scie I o. ph p?scri pt=sci _ arttext&pid=51679-44272011000200002. 3. Standards of Medical Care in Diabetes--2013. Diabetes Care. 2013;36(Supplement_ 1):511-566. doi:10.2337 /dc13-5011 4. Sociedade Brasileira de Diabetes. Diretrizes da Sociedade Brasileira de Diabetes 2017-2018. ln: Editora Clannad, ed. São Paulo; 2017: 12-381. www.editoraclannad.com.br. 5. Nickerson HD, Dutta S. Diabetic complications: current challenges and opportunities. J Cardiovasc Transl Res. 2012;5(4):375- 379. doi:10.1007 /s12265-012-9388-1 6. Laurence, L. Bruton, D. Knollman B. As Bases Farmacológicas Da Terapêutica de Goodman & Gilman. 13th ed. New York: McGraw-Hill Global Education; 2019. 7. McGill JB. Reexamining Misconceptions About -Blockers in Patients With Diabetes. Clin Diabetes. 2009;27(1):36-46. doi:10.2337 /diaclin.27.1.36 8. American Diabetes Association. Standards of Medical Care in Diabetes 2019. Diabetes Care. 2019;42(1):1-202. http:#care. diabetesjournals.org/content/diacare/suppl/2018/12/17 /42. Supplement_ 1.DC1/DC_ 42_51 _2019_UPDATED.pdf. 9. American Diabetes Association AD. 9. Pharmacologic Approaches to Glycemic Treatment: Standards of Medical Care in Diabetes-2019. Diabetes Care. 2019;42(Suppl 1):590-5102. doi:10.2337 /dc19-5009 10. Colberg L, Schmidt-Petersen L, Hansen MK, Larsen BS, Otnes 5. lncorrect storage of medicines and potential for cost savings. Eur J Hosp Pharm. 2017;24(3):167-169. doi:10.1136/ ejhpharm-2015-000744 11. Miot HA. Tamanho Da Amostra Em Estudos Clínicos e Experimentais. http:#www.scielo.br/pdf/jvb/v1 On4/v1 On4a01. 12. Sabater Hernández D, Milena M, Castro S, José M, Dáder F, Edição T. METODO DÁDER MANUAL DE SEGMENTO FARMACOTERAPEUTICO. 1st ed. (Edições Universitárias Lusófonas, ed.). Lisboa; 2009. http:#pharmcare.pt/wp-content/uploads/file/ Guia_dader.pdf. 13. Johnson EL, Feldman H, Butts A, et ai. Standards of medical care in diabetes-2019 abridged for primary care providers. Clin Diabetes. 2019;37(1 ):11-34. doi:10.2337 /cd18-0105 14. Evert AB, Dennison M, Gardner CD, et ai. Nutrition Therapy for Adults With Diabetes or Prediabetes: A Consensus Report. Diabetes Care. 2019;42(5): 731-754. dai: 10.2337 /dei 19-0014 15. Ramondi F. Não adesão ao tratamento medicamentoso contínuo: prevalência e determinantes em adultos de 40 anos e mais. Cad Saúde Pública. 2014;30(1):126-136. doi:10.1590/0102- 311X00092613 16. World Health Organization. Adherence to Long-Term Therapies: Evidence for Action. Switzerland; 2003. https:#apps.who. int/iris/bitstream/handle/10665/ 42682/9241545992.pdf. 17. Shamshirgaran SM, Mamaghanian A, Aliasgarzadeh A, Aiminisani N, lranparvar-Alamdari M, Ataie J. Age differences in diabetes-related complications and glycemic contrai. BMC Endocr Disord. 2017;17(1):25. doi:10.1186/s12902-017-0175-5 18. Sociedade Brasileira de Diabetes. Tratamento de Pacientes Idosos Com Diabetes. São Paulo; 205AD. https:#www.diabetes. org.br/profissionais/images/pdf/diabetes-tipo-2/020-Diretrizes-SBD-Tratamento-ldosos-pg198.pdf. 19. American Diabetes Association AD. Older Adults: Standards of Medical Care in Diabetes-2019. Diabetes Care. 2019;42(Suppl 1):5139-5147. doi:10.2337 /dc19-5012 20. Huang M-C, Hsu C-C, Wang H-5, Shin 5-J. Prospective Randomized Controlled Triai to Evaluate Effectiveness of Registered Dietitian-Led Diabetes Management on Glycemic and Diet Contrai in a Primary Care Setting in Taiwan. Diabetes Care. 2010;33(2):233-239. doi:10.2337 /dc09-1092 21. Abdul Aziz Ansari F, Farheena Abdul Aziz Ansari C. Study of various storage conditions on the pharmaceutical products and its implementation at retail store. Journal. 2017;6(9):475-478. www.thepharmajournal.com. 22. Organização Pan-Americana da Saúde. ENVELHECIMENTO ATIVO: UMA POLÍTICA. Brasília; 2005. www.opas.org.br. 23. Foppa A, Bevilacqua G, Pinto L. Atenção farmacêutica no contexto da estratégia de saúde da família. Brazilian J Pharm Sei. 2008;44(4):728-736. http:#www.revistas.usp.br/rbcf/article/ view/ 4434 7 / 4 7968. 24. McGill M, Biande L, Chan JCN, Khunti K, Lavalle FJ, Bailey CJ. The interdisciplinary team in type 2 diabetes management: Challenges and best practice solutions from real-world scenarios. J Clin Transl Endocrinol. 2017;7:21-27. doi:10.1016/j. jcte.2016.12.001 25. lquize R, Theodoro F, Carvalho C. Práticas educativas no paciente diabético e perspectiva do profissional de saúde: uma revisão sistemática. J Bras Nefrol. 2017;39(2):196-204. doi:10.5935/0101-2800.20170034 26. Wubben DP, Vivian EM. Effects of Pharmacist Outpatient lnterventions on Adults with Diabetes Mellitus: A Systematic Review. Pharmacotherapy. 2008;28(4):421-436. doi:10.1592/ phco.28.4.42

Published

2020-10-01

How to Cite

Pinto , L. H. ., Santos, M. B. P. ., Simões, T. L. ., Bitencourt, M. F. ., Martins, H. H. ., & Karstens, L. F. . (2020). Lack of non-quantitative effectiveness of drugs for diabetes: aspects of clinica! pharmacology and pharmaceutical chemistry. Saúde Coletiva (Barueri), 11(69), 8046–8057. https://doi.org/10.36489/saudecoletiva.2021v11i69p8046-8057

Issue

Section

Artigos Cientí­ficos