EFFECTS OF CANNABIS (CBD AND THC) ON THE ATHLETE'S BODY:
ITS POSSIBLE INFLUENCES IN SPORT
DOI:
https://doi.org/10.36489/saudecoletiva.2023v13i87p12841-12853Keywords:
Cannabidiol, THC, Athletes, SportsAbstract
Currently, cannabidiol (CBD) has been the subject of research as an adjuvant for the treatment of disorders, providing antioxidant, analgesic, anti-inflammatory and neuroprotective properties in both sports and clinical settings. CBD is structurally related to the main psychoactive compound Δ9-tetrahydrocannabinol (THC), which is responsible for the adverse effects of cannabis. CBD is not psychoactive, but some preclinical evidence suggests that it may be responsible for beneficial effects of cannabis for sports activities, such as decreased anxiety and extinction of fear memory. CBD can exert physiological, biochemical and psychological effects with potential to benefit athletes. However, more studies with sportsmen are needed before definitive conclusions can be reached about the usefulness of CBD in supporting athletic performance. Thus, the present study seeks, through a narrative literature review, to understand the effects of CBD and THC on the athlete's body and their possible influences on sport.
References
REFERÊNCIAS
World Anti-DopingAgency – WADA (Canadá). Summaryof Major ModificationsandExplanatory Notes: 2018 ProhibitedList [Internet]. Montreal: World Anti-DopingAgency; 2018 [citado em 2022 nov. 12]. Disponível em: https://www.wada-ama.org/sites/default/files/prohibited_list_2018_summary_of_modifications_en.pdf
Ware MA, Jensen D, Barrette A, Vernec A, Derman W. Cannabis andthe Health and Performance ofthe Elite Athlete. Clinical Journalof Sport Medicine. 2018 Sep;28(5):480–4.https://doi.org/10.1097/jsm.0000000000000650 DOI: https://doi.org/10.1097/JSM.0000000000000650
Bergamaschi MM, Crippa JAS. Whyshould Cannabis beConsidered Doping in Sports? Frontiers in Psychiatry. 2013 May 15;4.https://doi.org/10.3389/fpsyt.2013.00032 DOI: https://doi.org/10.3389/fpsyt.2013.00032
Browne N. CBD for athletes. Dynamic Chiropractic [Internet]. 2018 Aug [citado em 2022 nov. 12];52–5. Disponível em: https://www.dynamicchiropractic.com/digital/index.php?i=1243&a_id=58231&pn=52&r=t&Page=2
Lachenmeier DW, Habel S, Fischer B, Herbi F, Zerbe Y, Bock V, et al. Are sideeffectsofcannabidiol (CBD) productscausedbytetrahydrocannabinol (THC) contamination? F1000Research. 2019 Aug8;8:1394.https://doi.org/10.12688/f1000research.19931.1 DOI: https://doi.org/10.12688/f1000research.19931.1
Casey SL, Atwal N, Vaughan CW. Cannabis constituentsynergy in a mouse neuropathicpain model. PAIN. 2017 Dec;158(12):2452–60.https://doi.org/10.1097/j.pain.0000000000001051 DOI: https://doi.org/10.1097/j.pain.0000000000001051
Rother ET. Revisão sistemática X revisão narrativa. Acta Paulista de Enfermagem. 2007 Jun;20(2):v–vi.https://doi.org/10.1590/s0103-21002007000200001 DOI: https://doi.org/10.1590/S0103-21002007000200001
Cordeiro AM, Oliveira GM, Rentería JM, Guimarães CA. Revisão sistemática: uma revisão narrativa. Revista do Colégio Brasileiro de Cirurgiões. 2007 Dec;34(6):428–31.https://doi.org/10.1590/s0100-69912007000600012 DOI: https://doi.org/10.1590/S0100-69912007000600012
White CM. A Review ofHumanStudiesAssessingCannabidiol’s (CBD) TherapeuticActionsandPotential. The Journalof Clinical Pharmacology. 2019 Feb 7;59(7):923–34.https://doi.org/10.1002/jcph.1387 DOI: https://doi.org/10.1002/jcph.1387
Martin-Santos R, Crippa JA, Batalla A, Bhattacharyya S, Atakan Z, Borgwardt S, et al. Acuteeffectsof a single, oral dose of d9-tetrahydrocannabinol (THC) andcannabidiol (CBD) administration in healthyvolunteers. Currentpharmaceutical design. 2012;18(32):4966–79.https://doi.org/10.2174/138161212802884780 DOI: https://doi.org/10.2174/138161212802884780
Dalton WS, Martz R, Lemberger L, Rodda BE, Forney RB. Influenceofcannabidiolon delta-9-tetrahydrocannabinol effects. Clinical Pharmacology&Therapeutics. 1976 Mar;19(3):300–9.https://doi.org/10.1002/cpt1976193300 DOI: https://doi.org/10.1002/cpt1976193300
Filippis D, Esposito G, Cirillo C, Cipriano M, Winter BY, Scuderi C, et al. CannabidiolReduces Intestinal InflammationthroughtheControlofNeuroimmuneAxis. Gaetani S, editor. PLoS ONE. 2011 Dec 6;6(12):e28159.https://doi.org/10.1371/journal.pone.0028159 DOI: https://doi.org/10.1371/journal.pone.0028159
Gregorio D, McLaughlin RJ, Posa L, Ochoa-Sanchez R, Enns J, Lopez-Canul M, et al. Cannabidiolmodulatesserotonergictransmissionand reverses bothallodyniaandanxiety-like behavior in a model ofneuropathicpain. PAIN. 2019 Jan;160(1):136–50.https://doi.org/10.1097/j.pain.0000000000001386 DOI: https://doi.org/10.1097/j.pain.0000000000001386
Deiana S, Watanabe A, Yamasaki Y, Amada N, Arthur M, Fleming S, et al. Plasma andbrainpharmacokinetic profile ofcannabidiol (CBD), cannabidivarine (CBDV), Δ9-tetrahydrocannabivarin (THCV) andcannabigerol (CBG) in ratsandmicefollowing oral and intraperitoneal administrationand CBD actiononobsessive–compulsivebehaviour. Psychopharmacology. 2011 Jul 28;219(3):859–73.https://doi.org/10.1007/s00213-011-2415-0 DOI: https://doi.org/10.1007/s00213-011-2415-0
ElSohly MA, Radwan MM, Gul W, Chandra S, Galal A. Phytochemistryof Cannabis sativa L. Progress in thechemistryoforganic natural products. 2017;103:1–36.https://doi.org/10.1007/978-3-319-45541-9_1 DOI: https://doi.org/10.1007/978-3-319-45541-9_1
Burstein S. Cannabidiol (CBD) and its analogs: a review oftheireffectsoninflammation. Bioorganic& Medicinal Chemistry. 2015 Apr;23(7):1377–85.https://doi.org/10.1016/j.bmc.2015.01.059 DOI: https://doi.org/10.1016/j.bmc.2015.01.059
Rojas-Valverde D. Potential Role ofCannabidiolon Sports Recovery: A Narrative Review. Frontiers in Physiology. 2021 Aug 3;12.https://doi.org/10.3389/fphys.2021.722550 DOI: https://doi.org/10.3389/fphys.2021.722550
Fouad AA, Al-Mulhim AS, Jresat I. Cannabidioltreatmentamelioratesischemia/reperfusion renal injury in rats. Life Sciences. 2012 Sep;91(7-8):284–92.https://doi.org/10.1016/j.lfs.2012.07.030 DOI: https://doi.org/10.1016/j.lfs.2012.07.030
Docter S, Khan M, Gohal C, Ravi B, Bhandari M, Gandhi R, et al. Cannabis Use and Sport: A Systematic Review. Sports Health: A Multidisciplinary Approach. 2020 Feb 5;12(2):189–99.https://doi.org/10.1177/1941738120901670 DOI: https://doi.org/10.1177/1941738120901670
Trecroci A, Porcelli S, Perri E, Pedrali M, Rasica L, Alberti G, et al. EffectsofDifferent Training Interventionsonthe Recovery ofPhysicaland Neuromuscular Performance After a Soccer Match. JournalofStrengthandConditioningResearch. 2019 Jul;34:1.https://doi.org/10.1519/jsc.0000000000003269 DOI: https://doi.org/10.1519/JSC.0000000000003269
Gamelin FX, Cuvelier G, Mendes A, Aucouturier J, Berthoin S, Di Marzo V, et al. Cannabidiol in sport: Ergogenicorelse? PharmacologicalResearch. 2020 Jun;156:104764.https://doi.org/10.1016/j.phrs.2020.104764 DOI: https://doi.org/10.1016/j.phrs.2020.104764
McCartney D, Benson MJ, Desbrow B, Irwin C, Suraev A, McGregor IS. Cannabidioland Sports Performance: a Narrative Review ofRelevantEvidenceandRecommendations for Future Research. Sports Medicine - Open. 2020 Jul 6;6(1).https://doi.org/10.1186/s40798-020-00251-0 DOI: https://doi.org/10.1186/s40798-020-00251-0
Owens DJ, Twist C, Cobley JN, Howatson G, Close GL. Exercise-inducedmuscledamage: Whatis it, what causes it andwhat are thenutritionalsolutions? EuropeanJournalof Sport Science. 2018 Aug 15;19(1):71–85.https://doi.org/10.1080/17461391.2018.1505957 DOI: https://doi.org/10.1080/17461391.2018.1505957
Morelli KM, Brown LB, Warren GL. EffectofNSAIDson Recovery FromAcuteSkeletalMuscleInjury: A Systematic Review and Meta-analysis. The American Journalof Sports Medicine. 2017 Mar 29;46(1):224–33.https://doi.org/10.1177/0363546517697957 DOI: https://doi.org/10.1177/0363546517697957
Sakr M, Wilson L. Aspirinandtheriskofintracranialcomplicationsfollowingheadinjury. Emergency Medicine Journal. 2005 Dec 1;22(12):891–2.https://doi.org/10.1136/emj.2005.031740 DOI: https://doi.org/10.1136/emj.2005.031740
Kasper AM, Sparks SA, Hooks M, Skeer M, Webb B, Nia H, et al. High PrevalenceofCannabidiol Use Within Male Professional Rugby Union and League Players: A Quest for Pain Reliefand Enhanced Recovery. InternationalJournalof Sport NutritionandExerciseMetabolism. 2020 Sep 1;30(5):315–22.https://doi.org/10.1123/ijsnem.2020-0151 DOI: https://doi.org/10.1123/ijsnem.2020-0151