Safety and Effectiveness of a Protocol for Dental Care of Anticoagulated Patients at a Hospital Level
DOI:
https://doi.org/10.36489/saudecoletiva.2025v15i97p16180-16195Keywords:
Anticoagulants, Dental treatment, HemorrhagesAbstract
Introduction: Anticoagulant therapy is essential to prevent thromboembolic events in patients with cardiovascular disorders, but it increases the risk of hemorrhagic complications during dental procedures. Management protocols vary between maintaining, adjusting, or suspending anticoagulants, combined with the use of local hemostatics to mitigate these risks. Objective: To evaluate the effectiveness of a protocol for performing dental procedures with potential bleeding in anticoagulated patients. This protocol was developed and is proposed by the Municipal Health Department of Belo Horizonte,
Minas Gerais – SMSA/PBH, for procedures carried out in its healthcare network. Methodology: This is a retrospective quantitative study based on the analysis of medical records of patients treated by the Special Dental Diagnosis and Treatment Service (SEDTO) of the Clinics Hospital at the Federal University of Minas Gerais (HC-UFMG), on an outpatient basis, from October 2020 to November 2023, according to medical requests. Results: A total of 174 medical records of patients using oral anticoagulants were evaluated, in which 292 procedures were performed and 8 cases of hemorrhagic complications were observed. Conclusion: The protocol for the care of anticoagulated patients provided by PBH is effective and enables safe dental procedures for this population. To manage anticoagulated patients in dentistry, thorough planning is essential, always respecting each patient’s individuality and needs.
References
European Heart Rhythm Association; European Association for Cardio-Thoracic Surgery, Camm AJ, et al. Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC) [published correction appears in Eur Heart J. 2011 May;32(9):1172]. Eur Heart J. 2010;31(19):2369-2429. DOI: https://doi.org/10.1093/eurheartj/ehq278
Anderson FA Jr, Spencer FA. Risk factors for venous thromboembolism. Circulation. 2003;107(23 Suppl 1):I9-I16. DOI: https://doi.org/10.1161/01.cir.0000078469.07362.e6
Lu SY, Lin LH, Hsue SS. Management of dental extractions in patients on warfarin and antiplatelet therapy. J Formos Med Assoc. 2018;117(11):979-986. DOI: https://doi.org/10.1016/j.jfma.2018.08.019
Gerzon AS, et al. Cirurgias odontológicas em pacientes sob terapia com antiagregante plaquetário e anticoagulante oral: Revisão de literatura. Dental Press Publishing. 2016;13(2):98-105.
Granger CB, Alexander JH, McMurray JJ, et al. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2011;365(11):981-992. DOI: https://doi.org/10.1056/nejmoa1107039
Gunawardena T. Direct oral anticoagulants: A review for the non-specialist. Hematol Rep. 2021;13(4):9239. DOI: https://doi.org/10.4081/hr.2021.9239
Miller CS, Grandi SM, Shimony A, Filion KB, Eisenberg MJ. Meta-analysis of efficacy and safety of new oral anticoagulants (dabigatran, rivaroxaban, apixaban) versus warfarin in patients with atrial fibrillation. Am J Cardiol. 2012;110(3):453-460. DOI: https://doi.org/10.1016/j.amjcard.2012.03.049
Wigle P, Hein B, Bloomfield HE, Tubb M, Doherty M. Updated guidelines on outpatient anticoagulation. Am Fam Physician. 2013;87(8):556-566. Disponível em: https://www.aafp.org/pubs/afp/issues/2013/0415/p556.html
Abayon M, Kolokythas A, Harrison S, Elad S. Dental management of patients on direct oral anticoagulants: Case series and literature review. Quintessence Int. 2016;47(8):687-696. DOI: https://doi.org/10.3290/j.qi.a36325
Pedrosa MS, et al. Cirurgias orais em pacientes em uso de Varfarina. Revista Bahiana de Odontologia. 2016;7(2):132-139. Disponível em: https://journals.bahiana.edu.br/index.php/odontologia/article/view/907
Mingarro-de-León A, Chaveli-López B, Gavaldá-Esteve C. Dental management of patients receiving anticoagulant and/or antiplatelet treatment. J Clin Exp Dent. 2014;6(2):e155-e161. Published 2014 Apr 1. DOI: https://doi.org/10.4317/jced.51215
Andrade MVS, Andrade LAP, Bispo AF, Freitas LA, Andrade MQS, Feitosa GS, Feitosa-Filho GS. Avaliação da Intensidade de Sangramento de Procedimentos Odontológicos em Pacientes Anticoagulados com Varfarina ou Dabigatrana. Arq. Bras. Cardiol. 2018;111(3):394-9. DOI: https://dx.doi.org/10.5935/abc.20180137
Inchingolo F, Inchingolo AM, Piras F, et al. Management of Patients Receiving Anticoagulation Therapy in Dental Practice: A Systematic Review. Healthcare (Basel). 2024;12(15):1537. Published 2024 Aug 2. DOI: https://doi.org/10.3390/healthcare12151537
ADA Science Institute. Anticoagulant and antiplatelet medications and dental procedures. Disponível em: https://www.ada.org/en/member-center/oral-health-topics/anticoagulant-antiplatelet-medications-and-dental
Prefeitura de Belo Horizonte. Protocolo de anticoagulação ambulatorial. Prefeitura Municipal de Belo Horizonte. 2021. Disponível em: https://prefeitura.pbh.gov.br/sites/default/files/estrutura-de-governo/saude/2021/protocolo_anticoagulacao_ambulatorial.pdf.
Roser SM, Rosenbloom B. Continued anticoagulation in oral surgery procedures. Oral Surg Oral Med Oral Pathol. 1975;40(4):448-457. DOI: https://doi.org/10.1016/0030-4220(75)90241-8
Barbosa LM, et al. Protocolo de tratamento cirúrgico de pacientes em uso de anticoagulante e antiagregante plaquetário. Research, Society and Development. 2020;9(9):726-733. DOI: http://dx.doi.org/10.33448/rsd-v9i9.7726
Campos FHO et al. Immediate laser-induced hemostasis in anticoagulated rats subjected to oral soft tissue surgery: a double-blind study. Braz Oral Res. 2018;32:e56. DOI: https://doi.org/10.1590/1807-3107bor-2018.vol32.0056
Mata A, et al. Normas de orientação clínica dos pacientes hipocoagulados em medicina dentária. Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial. 2018;59(3):131-139. DOI: http://doi.org/10.24873/j.rpemd.2018.11.241
Dézsi CA, Dézsi BB, Dészi AD. Management of dental patients receiving antiplatelet therapy or chronic oral anticoagulation: a review of the latest evidence. European Journal of General Practice. 2017;23(1):196-201. DOI: https://doi.org/10.1080/13814788.2017.1350645
Salanti G, Ades AE, Ioannidis PA. Graphical methods and numerical summaries for presenting results from multiple-treatment meta-analysis: An overview and tutorial. Journal of Clinical Epidemiology. 2011;64(2):163-171.
Caramelli B, Fornari LS. Manejo perioperatório dos novos anticoagulantes orais. Revista da Sociedade de Cardiologia do Estado de São Paulo. 2017;27(3):195-200. Disponível em: https://docs.bvsalud.org/biblioref/2021/08/875314/02_revistasocesp_v27_03.pdf
Rocha AL, Souza AF, Martins MAP, et al. Oral surgery in patients under antithrombotic therapy: perioperative bleeding as a significant risk factor for postoperative hemorrhage. Blood Coagul Fibrinolysis. 2018;29(1):97-103. DOI: https://doi.org/10.1097/mbc.0000000000000677
Elad S, Marshall J, Meyerowitz C, Connolly G. Novel anticoagulants: general overview and practical considerations for dental practitioners. Oral Dis. 2016;22(1):23-32. DOI: https://doi.org/10.1111/odi.12371
Menezes JM. Tromboprofilaxia em pacientes hospitalizados: uma revisão narrativa [Trabalho de Conclusão de Curso]. Brasília (DF): Centro Universitário de Brasília; 2018. Disponível em: https://repositorio.uniceub.br/jspui/handle/prefix/13010








