The Effect of Photobiomodulation on Pain Management and Functionality in Knee Osteoarthritis: A Systematic Review Protocol
DOI:
https://doi.org/10.36489/saudecoletiva.2025v16i98p16616-16625Keywords:
Knee osteoarthritis, Photobiomodulation, Pain, Functionality, Systematic reviewAbstract
Objective: This systematic review protocol aims to analyze the effect of photobiomodulation on pain management and functionality in patients with knee osteoarthritis. Method: Registered in PROSPERO and following PRISMA guidelines, it will include randomized clinical trials using photobiomodulation in patients with knee osteoarthritis. The search will be conducted in MEDLINE, COCHRANE, EMBASE, AMED, SCOPUS, and PEDRO databases. The selection and extraction of data will be carried out by two independent reviewers, with a third to resolve any discrepancies. The risk of bias will be assessed using the PEDro scale. The data synthesis will include meta-analysis with random effects models and evaluation of the quality of evidence using the GRADE system. Conclusion: This review will provide a comprehensive overview of the effectiveness of photobiomodulation in managing pain and improving functionality in patients with knee osteoarthritis, contributing to evidence-based clinical practice.
References
Hunter DJ, Schofield D, Callander E. The individual and socioeconomic impact of osteoarthritis. Nat Rev Rheumatol. 2014;10(7):437-41.
Di Pietro F, Alastrue A, Piscitelli P, Balius R, Oliva F, Maffulli N. Osteoarthritis: a review of pathophysiology and current therapeutic strategies. J Orthop Traumatol. 2014;15(3):157-68.
Altman R, Asch E, Bloch D, Bole G, Borenstein D, Brandt K, et al. Development of criteria for the classification and reporting of osteoarthritis: classification of osteoarthritis of the knee. Arthritis Rheum. 1986;29(8):1039-49.
Bitton R. The economic burden of osteoarthritis. Am J Manag Care. 2009;15(8 Suppl). doi:10.1002/art.1780290311.
Fautrel B, Hilliquin P, Rozenberg S, Allaert FA, Dougados M, Ravaud P. Impact of osteoarthritis: Results of a nationwide survey of 10,000 patients consulting for OA. Joint Bone Spine. 2005;72(3):235-40. doi:10.1016/j.jbspin.2004.08.009.
GBD 2019 Diseases and Injuries Collaborators. Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 2020;396(10258):1204-22.
Hunter DJ, Bierma-Zeinstra S. Osteoarthritis. Lancet. 2019;393(10182):1745-59.
Egloff C, Hügle T, Valderrabano V. Biomechanics and pathomechanisms of osteoarthritis. Swiss Med Wkly. 2012;142:w13583.
Felson DT. Osteoarthritis as a disease of mechanics. Osteoarthritis Cartilage. 2011;19(1):20-5.
Alfredo PP, Bjordal JM, Dreyer SH, Meneses SRF, Zaguetti G, Ovanessian V, et al. Efficacy of photobiomodulation therapy associated with exercises in knee osteoarthritis: a randomized double-blind placebo-controlled trial. Osteoarthritis Cartilage. 2018;26(5):634-43.
Alfredo PP, Bjordal JM, Dreyer SH, Meneses SRF, Zaguetti G, Ovanessian V, et al. Efficacy of photobiomodulation therapy associated with exercises in knee osteoarthritis: a randomized double-blind placebo-controlled trial. Osteoarthritis Cartilage. 2022;26(5):634-43.
Ahmad MA, Hamid MSA, Yusof A. Effects of low-level laser therapy in patients with knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials. Physiotherapy. 2022;114:31-9.
Stausholm MB, Joensen J, Lopes-Martins RÁB, Álvaro B, Sæbø H, Lund H, et al. Efficacy of low-level laser therapy on pain and disability in knee osteoarthritis: Systematic review and meta-analysis of randomised placebo-controlled trials. BMJ Open. 2019;9:e031142. doi:10.1136/bmjopen-2019-031142.
Stausholm MB, Naterstad IF, Alfredo PP, Couppé C, Fersum KV, Leal-Junior ECP, et al. Short- and Long-Term Effectiveness of Low-Level Laser Therapy Combined with Strength Training in Knee Osteoarthritis: A Randomized Placebo-Controlled Trial. J Clin Med. 2022;11(12):3446. doi:10.3390/jcm11123446.
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71.
Schünemann HJ, Higgins JPT, Vist GE, Glasziou P, Akl EA, Skoetz N, et al. GRADE handbook for grading quality of evidence and strength of recommendations. Cochrane. 2020.








