Breast carcinoma: Molecular classification using immunohistochemistry

Authors

  • David Marlon Vieira Santos
  • Luana Guimaraes da Silva
  • Paulo Celso Pardi
  • Gustavo Alves Andrade dos Santos
  • Marcos Emanuel de Alcântara Segura
  • Joaquim da Silva Xavier

DOI:

https://doi.org/10.36489/saudecoletiva.2020v10i58p3863-3874

Keywords:

Breast, Carcinoma, Cancer, Neoplasm, Immunohistochemistry

Abstract

Objective: To classify different histological types for mammary carcinoma, invasive type, with the aid of immunohistochemistry. Methods: We selected 3033 positive cases, 2433 of the invasive type, which were classified into four groups: Luminal A, luminal B, HER2-eriched, and Basal like (triple negative). We conducted a retrospective observational study between the years 2011 and 2016.Results: 2062 (84.4%) of the related to CDI SOE, following the items in decreasing order: CLI (11.3); Invasive micropapillary carcinoma (1.11%) and other types with incidence less than 1%. Conclusion: This study allowed a histological differentiation and characterization of the IHQ profile of invasive mammary carcinoma over a 6 years in the Federal District.

Author Biographies

David Marlon Vieira Santos

Biologist. Specialist in Human Anatomy at the Pontificia Universidade Catolica de Goias (GO), focusing on teaching (2018).

Luana Guimaraes da Silva

Nurse. Graduation in Nursing from FACESA.

Paulo Celso Pardi

Biomedico (UMC), Specialist in Gerontology (UNIDERP) and Master and Doctor in Morphology (UNIFESP).

Gustavo Alves Andrade dos Santos

Biochemical Pharmacist; Post graduated in Hospital Pharmacy; PhD in Biotechnology; Master in Pharmacy. Postdoctoral student in Anatomy and Surgery at the Faculty of Medicine, USP, Ribeirão Preto.

Marcos Emanuel de Alcântara Segura

Doctor. Graduation in Medicine from the University of Brasilia (2003), Master in Medical Sciences from the University of Brasilia (2008).

Joaquim da Silva Xavier

Biologist. Graduation in Biology from Universidade Catolica de Brasilia (2002) and Master in Molecular Pathology from Universidade de Brasilia (2006).

Published

2020-11-24

How to Cite

Vieira Santos , D. M. ., Guimaraes da Silva, L. ., Celso Pardi, P. ., Alves Andrade dos Santos, G. ., de Alcântara Segura, M. E. ., & da Silva Xavier , J. . (2020). Breast carcinoma: Molecular classification using immunohistochemistry . Saúde Coletiva (Barueri), 10(58), 3863–3874. https://doi.org/10.36489/saudecoletiva.2020v10i58p3863-3874

Issue

Section

Artigos Cientí­ficos